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Livestreamed Session
Livestreamed Session

IMI
Session Type: Symposium

S07--Game of Thrones: Inflammation Initiators & Drivers Across the Lifespan

Thursday, October 23, 2025
2:30 PM - 4:30 PM PDT
Location:433-434

Inflammation is a constant battleground in CF disease. Its origins and progression vary dramatically over time and the effect of modulator therapy is complex. This session will explore the intricate "chicken and egg" dynamic between infection and inflammation, with translational insights from animal models. We’ll then delve into the bidirectional relationship between chronic infection and host immune responses, highlighting how this interplay shapes CF disease. We will discuss critical immune targets for therapy, addressing the fine line between preserving essential host defense and minimizing harmful inflammatory responses. Finally, we will examine how factors such as sex, genetic mutations, and biological heterogeneity influence disease variability. Join us for a deep dive into the battles that define inflammation across the CF lifespan—and the future strategies to tip the balance toward health.

Learning Objectives:

  • Describe the interplay between infection and inflammation in CF disease initiation across the lifespan, incorporating insights from preclinical and clinical research models.
  • Assess the dynamic relationship between chronic infection and host immune responses, and discuss its relevance for the development of targeted therapeutic interventions.
  • Examine the impact of sex differences, genetic mutations, and biological heterogeneity on the variability of CF inflammatory disease phenotypes.

Presentations:

  • 2:30 PM - 4:30 PM PDT
    S07.1- Initiation: Chicken and Egg (Infection and Inflammation)

    Speaker: Nikolai Klymiuk, PhD – TU Munich

  • 2:30 PM - 4:30 PM PDT
    S07.2- Nightwatch at the Mucosal Wall: A Tale of Host-Pathogen Dynamics

    Speaker: Camilla Margaroli – University of Alabama at Birmingham

  • 2:30 PM - 4:30 PM PDT
    S07.3- Immune Targets for Therapies: What is Essential for Host Defense? What is Deleterious?

    Speaker: Emanuela M. Bruscia, PhD – Yale University School of Medicine

  • 2:30 PM - 4:30 PM PDT
    S07.4- Disease variability: sex and mutation and heterogeneity

    Speaker: Clemente J. Britto-Leon, MD – Yale University