W22--Reprogramming Immune Dysfunction in CF

Chair(s)

• 

  Camilla Margaroli

  Department of Medicince
  University of Alabama at Birmingham
• CB

  Clemente Britto-Leon, MD

  Yale University

This session will focus on challenges related to chronic inflammation in the era of CFTR modulators and novel opportunities for therapeutic intervention targeting the immune system in CF.

Presentations:

• 10:15 AM - 12:15 PM PDT

  W22.1- Bioenergetic and metabolic derangements in circulating CF neutrophils are further enhanced by transmigration to the CF airway milieu
  

  Speaker: Kathryn M. Crotty, PhD – Emory University
• 10:15 AM - 12:15 PM PDT

  W22.2- Chronic cystic fibrosis airway disease is driven by MALAT1+ extracellular vesicles via an HDAC11-dependent mechanism.
  

  Speaker: Brian Dobosh, PhD – Emory University
• 10:15 AM - 12:15 PM PDT

  W22.3- LAP it up: The role of LC3 Associated Phagocytosis (LAP) in Cystic Fibrosis (CF)
  

  Speaker: Mahesh K. Shrestha, MBiol, MBA – Emory University
• 10:15 AM - 12:15 PM PDT

  W22.4- Restoration of ezrin via calpain inhibition reinstates immune function in cystic fibrosis alveolar macrophages.
  

  Speaker: Ravindra Gudneppanavar, PhD – Yale University School of Medicine
• 10:15 AM - 12:15 PM PDT

  W22.5- T cell memory polyamine metabolism and heterogeneity in CF exacerbation outcomes
  

  Speaker: Milene T. Saavedra, Denver, USA – National Jewish Health