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Gaurav Sahay, PhD

college of pharmacy- Oregon state university

Gaurav Sahay, Ph.D. is a Professor in the Department of Pharmaceutical Sciences and Director of the Center of Innovative Drug Delivery and Imaging (CIDDI) at the College of Pharmacy, Oregon State University. His research group develops cutting-edge nanotechnology-based platforms, with a strong focus on lipid-based nanoparticles (LNPs) for the delivery of messenger RNA (mRNA) therapeutics targeting cystic fibrosis, retinal degeneration, and cancer. Dr. Sahay is internationally recognized for his pioneering work in dissecting intracellular trafficking pathways critical for nucleic acid delivery and for devising novel strategies to overcome the endosomal escape barrier—a central challenge in drug delivery. His laboratory has introduced innovative methods to measure and improve cytosolic delivery of nucleic acids, driving both mechanistic insights and translational advances. He has authored more than 80 peer-reviewed publications in leading journals including Science Advances, Nature, Nature Biotechnology, Nature Nanotechnology, Nature Communications, Journal of Controlled Release, and Nano Letters. His work has been recognized through numerous awards, including the 2013 AAPS Postdoctoral Fellow Award, the 2015 CRS T. Nagai Award, the 2016 AACP New Investigator Award, the 2019 OHSU Distinguished Faculty Senate Award for Collaboration, the 2020 Phi Kappa Phi OSU Emerging Scholar Award, and the 2020 CMBE Young Innovator Award. As Principal Investigator, Dr. Sahay has secured significant research funding from the National Institutes of Health, the Cystic Fibrosis Foundation, DARPA, and leading biotechnology companies. He also contributes to innovation and translation as co-founder of Enterx Bio and RNAvax Bio, and as a consultant and scientific advisory board member to biotech and venture capital firms. His leadership extends to the broader scientific community, having served as Chair of the 2018 NanoMedicine and Drug Delivery Symposium (NanoDDS) and as a standing member of the NIH Study Section on Innovations in NanoSystems and Nanotechnology.

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