Emory University
Brian Dobosh, Ph.D. Emory University
a) I study how waves of recruited immune cells communicate and propagate a phenotype across a tissue during stress conditions. I primarily focus on innate immune cells such as monocytes and neutrophils and the role of extracellular vesicles as both biomarkers and functional units. My long-term goal is to develop host-directed innate immunotherapies for more effective clearance of bacterial, viral, and fungal pathogens and promotion of wound-healing.” I currently have projects across diseases including cystic fibrosis, chronic obstructive pulmonary disease, influenza and SARS-CoV-2 viral infections, and tuberculosis.
b) Since innate immune cells have a high rate of uptake of extracellular vesicles (EV), they are a prime candidate for extracellular vesicle-mediated therapies. To this end, I am developing a designer EV toolkit (DEVkit) to engineer extracellular vesicles with custom RNA and protein cargo and targeting capabilities. Another long-term goal of mine is to utilize synthetic biology for more standardized, precise, and robust generation of EVs and other therapeutic delivery vehicles.
Friday, October 24, 2025
10:15 AM - 12:15 PM PDT