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Livestreamed Session
Livestreamed Session

EPP
Session Type: Workshop

W09--Gastrointestinal Involvement in CF

Thursday, October 23, 2025
10:15 AM - 12:15 PM PDT
Location:Terrace Suite

This session will incorporate clinical and basic science to explore the physiologic mechanisms that cause gastrointestinal involvement in CF. We will start by exploring the impact of CFTR on pancreatic duct cells as well as PDAC cells in human cell lines as well as a pig model. The session will then shift to the intestinal involvement observed in CF focusing on glycolysis pathways and metabolic dysregulation at the cellular level that may drive intestinal inflammation as well as summarize the changes in the microbiome and abdominal symptoms observed in the RECOVER study. Finally, we will explore the gut-neuro axis in CF using a gut-on-a-chip platform which compliments a clinical study utilizing gastric mapping to evaluate intestinal motility.

Presentations:

  • 10:15 AM - 12:15 PM PDT
    W09.1- CFTR Modulators Suppress CF Pancreas and Pancreatic Duct Cancer Cell Proliferation by Targeting Cell Cycle Pathway Genes

    Speaker: Yunxia O'Malley – Pediatrics

  • 10:15 AM - 12:15 PM PDT
    W09.2- Metabolic shifts in the Cystic Fibrosis mouse small intestine: Potential transcriptional drivers of glycolysis

    Speaker: Derek Host – Case Western Reserve University

  • 10:15 AM - 12:15 PM PDT
    W09.3- Changes in fecal microbiome and relationships with gut inflammation and abdominal symptoms over 6 months of treatment with Elexacaftor/Tezacaftor/Ivacaftor in people with CF – results from RECOVER

    Speaker: Paul McNally – RCSI University of Medicine and Health Sciences

  • 10:15 AM - 12:15 PM PDT
    W09.4- A “gut-on-a-chip” model to study the gut-EN-sensory neuron interface in CF

    Speaker: Oscar O. Morales, MSc – University of Saskatchewan

  • 10:15 AM - 12:15 PM PDT
    W09.5- Differences in Gastric Slow Wave Propagation in Youth and Young Adults with CF Compared to Healthy Controls

    Speaker: Rosara Bass, MD, MS – Nationwide Children's Hospital