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Livestreamed Session
Livestreamed Session

Lunch & Learn

PTAC/CFTR

LL05--Which Cell Types Are the Ideal Therapeutic Targets?

Thursday, October 23, 2025
12:30 PM - 2:00 PM PDT
Location: 331-332
Which cell types matter most in CFTR restoration —and do cell types even matter? As CFTR-directed gene therapies advance, targeting the right cells is more critical than ever. Despite major strides, debate continues over which airway epithelial cell types are key to CFTR function. Advances in single-cell transcriptomic technologies have generated high-resolution maps of CFTR transcript distribution across diverse epithelial populations, accelerating efforts to link CFTR expression to physiological function in key cell types, including pulmonary ionocytes and secretory cells. This session will highlight the latest discoveries and evolving perspectives on cell-type-specific CFTR function, helping move us closer to the ideal cellular targets for CF therapies.

Learning Objectives:

  • Summarize the most recent findings of the function of CFTR across the diversity of airway epithelial cell types
  • Discuss the feasibility of targeting specific cell types
  • Compare the efficacy of restoring CFTR function across the cell types