W29--Don’t STOP Believing: Solutions to Readthrough of PTCs

Chair(s)

• 

  Margarida Amaral, PhD

  FCUL-Faculty of Sciences, University of Lisboa
• KT

  Kari Thrasher, PhD

  University of Rochester School of Medicine and Dentistry

Presentations:

• 10:15 AM - 12:15 PM PDT

  W29.1- Genome-Wide KO Screen (GWS) to uncover genes promoting Premature Termination Codon readthrough
  

  Speaker: Eric Wong, MS – Cystic Fibrosis Foundation
• 10:15 AM - 12:15 PM PDT

  W29.2- CFTR glutamic acid nonsense mutations are rescued by a newly engineered suppressor transfer RNA in a variant-dependent manner
  

  Speaker: Yunjie Huang, PhD – Indiana University
• 10:15 AM - 12:15 PM PDT

  W29.3- Targeted eRF3a degradation amplifies nonsense mutation readthrough in a CF murine model.
  

  Speaker: Lisa Nicholson – Case Western Reserve University.
• 10:15 AM - 12:15 PM PDT

  W29.4- Small Molecules as Aminoglycoside Enhancers to promote Readthrough for the Treatment of Cystic Fibrosis
  

  Speaker: Corinne E. Augelli-Szafran, PhD, MS – Heersink School of Medicine, University of Alabama at Birmingham
• 10:15 AM - 12:15 PM PDT

  W29.5- Discovery of non-aminoglycoside small molecules that enhance eRF3 degrader-induced translational readthrough of CFTR nonsense mutations
  

  Speaker: Steven Rowe