W16--Host Response to CF Airway Infections

Friday, October 24, 2025

7:45 AM - 9:45 AM PDT

Location:Signature Room

Chair(s)

Sophia Goldman, BSc

McGIll University
Tania Wong, PhD

Rutgers New Jersey Medical School

This session will delve into how pathogens influence host signaling and metabolism to sustain chronic pulmonary infection. Attendees will explore the intricate host-pathogen interactions, gaining valuable insights into how this understanding can drive the development of innovative treatment for cystic fibrosis (CF).

Learning Objectives:

Understand the mechanisms by which pathogens manipulate host signaling and metabolism to establish chronic pulmonary infections
Explore the interplay between pathogens and host biology and how this knowledge can be applied to develop new strategies for treating cystic fibrosis
Utilize cystic fibrosis as a model to enhance our understanding of host responses to pathogens that promote chronic airway infections

Presentations:

7:45 AM - 9:45 AM PDT

W16.1- Hidden in plain sight: Rediscovering Mast Cells in Cystic Fibrosis
Speaker: Irina Miralda, PhD – Emory University
7:45 AM - 9:45 AM PDT

W16.2- CFTR modulator impact on naive T cell programming
Speaker: Milene T. Saavedra, Denver, USA – National Jewish Health
7:45 AM - 9:45 AM PDT

W16.3- Evolution and pathoadaptation of Pseudomonas aeruginosa through the gut-lung axis in cystic fibrosis
Speaker: Rebecca A. Valls, PhD – Dartmouth College
7:45 AM - 9:45 AM PDT

W16.4- Displacement of methicillin-resistant Staphylococcus aureus following ETI treatment for CF.
Speaker: Jose A. Zapata, Biology, B.S. – University of Iowa
7:45 AM - 9:45 AM PDT

W16.5- Tracking Pseudomonas aeruginosa adaptation under CFTR modulator therapy: a longitudinal multi-omics study
Speaker: Laura Veschetti, PhD – Infections and Cystic Fibrosis Unit, San Raffaele Scientific Institute